Ontology highlight
ABSTRACT:
SUBMITTER: Adkison K
PROVIDER: S-EPMC5836851 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Adkison Kimberly K Wolstenholme Allen A Lou Yu Y Zhang Zhiping Z Eld Amy A Perger Teodora T Vangerow Harald H Hayward Katy K Shaefer Mark M McCoig Cynthia C
Clinical pharmacology and therapeutics 20171211 3
In children aged ≤4 years, the relative bioavailability of lamivudine oral solution was 37% lower than that of a tablet formulation. An open-label, four-way crossover study was conducted in healthy adults to evaluate the effect of sorbitol, a common liquid excipient, on the pharmacokinetics of lamivudine oral solution (ClinicalTrials.gov identifier, NCT02634073). Sixteen subjects were randomized to one of four sequences consisting of four doses of lamivudine 300 mg (10 mg/mL) alone or with sorbi ...[more]