Ontology highlight
ABSTRACT:
SUBMITTER: Kim KY
PROVIDER: S-EPMC5073315 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kim Kwang-Youn KY Jang Hyun-Jun HJ Yang Yong Ryoul YR Park Kwang-Il KI Seo JeongKon J Shin Il-Woo IW Jeon Tae-Il TI Ahn Soon-Cheol SC Suh Pann-Ghill PG Osborne Timothy F TF Seo Young-Kyo YK
Scientific reports 20161021
Dysregulated autophagy is associated with steatosis and non-alcoholic fatty liver disease (NAFLD), however the mechanisms connecting them remain poorly understand. Here, we show that co-administration of lovastatin and ezetimibe (L/E) significantly reverses hepatic triglyceride accumulation concomitant with an increase in SREBP-2 driven autophagy in mice fed a high-fat diet (HFD). We further show that the statin mediated increase in SREBP-2 directly activates expression of patatin-like phospholi ...[more]