Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.
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ABSTRACT:
SUBMITTER: Jin J
PROVIDER: S-EPMC6072278 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.
Jin Jingling J Valanejad Leila L Nguyen Thuy Phuong TP Lewis Kyle K Wright Mary M Cast Ashley A Stock Lauren L Timchenko Lubov L Timchenko Nikolai A NA
Cell reports 20160630 3
The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on Ser193 and formation of C/EBPα-p300 complexes, resulting in hepatic steatosis, fibrosis, and hepatocellular carcinoma (HCC). The disruption of this pathway in cdk4-resistant C/EBPα-S ...[more]
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