Ontology highlight
ABSTRACT:
SUBMITTER: Bonasera SJ
PROVIDER: S-EPMC5076456 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bonasera Stephen J SJ Arikkath Jyothi J Boska Michael D MD Chaudoin Tammy R TR DeKorver Nicholas W NW Goulding Evan H EH Hoke Traci A TA Mojtahedzedah Vahid V Reyelts Crystal D CD Sajja Balasrinivasa B Schenk A Katrin AK Tecott Laurence H LH Volden Tiffany A TA
Aging 20160901 9
We describe age-related molecular and neuronal changes that disrupt mobility or energy balance based on brain region and genetic background. Compared to young mice, aged C57BL/6 mice exhibit marked locomotor (but not energy balance) impairments. In contrast, aged BALB mice exhibit marked energy balance (but not locomotor) impairments. Age-related changes in cerebellar or hypothalamic gene expression accompany these phenotypes. Aging evokes upregulation of immune pattern recognition receptors and ...[more]