Ontology highlight
ABSTRACT:
SUBMITTER: Boddum K
PROVIDER: S-EPMC5133667 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Boddum Kim K Jensen Thomas P TP Magloire Vincent V Kristiansen Uffe U Rusakov Dmitri A DA Pavlov Ivan I Walker Matthew C MC
Nature communications 20161125
Astrocytes are ideally placed to detect and respond to network activity. They express ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also express transporters that regulate the extracellular concentration of neurotransmitters. Here we report a previously unrecognized role for the astrocytic GABA transporter, GAT-3. GAT-3 activity results in a rise in astrocytic Na<sup>+</sup> concentrations and a consequent increase in astrocytic Ca<sup>2+</sup> through Na<su ...[more]