Ontology highlight
ABSTRACT:
SUBMITTER: Engel BJ
PROVIDER: S-EPMC5078052 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Engel Brian J BJ Bowser Jessica L JL Broaddus Russell R RR Carson Daniel D DD
Oncotarget 20160501 22
The current standard of care for endometrial cancer patients involves hysterectomy with adjuvant radiation and chemotherapy, with no effective treatment for advanced and metastatic disease. MUC1 is a large, heavily glycosylated transmembrane protein that lubricates and protects cell surfaces and increases cellular signaling through the epidermal growth factor receptor (EGFR). We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and C ...[more]