Ontology highlight
ABSTRACT:
SUBMITTER: Rajabi H
PROVIDER: S-EPMC5547076 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Rajabi Hasan H Hiraki Masayuki M Tagde Ashujit A Alam Maroof M Bouillez Audrey A Christensen Camilla L CL Samur Mehmet M Wong Kwok-Kin KK Kufe Donald D
Scientific reports 20170807 1
The EZH2 histone methyltransferase is a member of the polycomb repressive complex 2 (PRC2) that is highly expressed in diverse human cancers and is associated with a poor prognosis. MUC1-C is an oncoprotein that is similarly overexpressed in carcinomas and has been linked to epigenetic regulation. A role for MUC1-C in regulating EZH2 and histone methylation is not known. Here, we demonstrate that targeting MUC1-C in diverse human carcinoma cells downregulates EZH2 and other PRC2 components. MUC1 ...[more]