Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC5078599 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Xie Xuping X Zou Jing J Shan Chao C Yang Yujiao Y Kum Dieudonné Buh DB Dallmeier Kai K Neyts Johan J Shi Pei-Yong PY
EBioMedicine 20160914
The current epidemic of Zika virus (ZIKV) has underscored the urgency to establish experimental systems for studying viral replication and pathogenesis, and countermeasure development. Here we report two ZIKV replicon systems: a luciferase replicon that can differentiate between viral translation and RNA synthesis; and a stable luciferase replicon carrying cell line that can be used to screen and characterize inhibitors of viral replication. The transient replicon was used to evaluate the effect ...[more]