Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC5079247 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gao Yang Y Meyer Jennifer R JR Nelson Scott W SW
Protein science : a publication of the Protein Society 20160916 11
The Mre11-Rad50 (MR) protein complex, made up of a nuclease and ATPase, respectively, is involved in the processing of double-strand breaks as part of an intricate mechanism for their repair. Although it is clear that the MR complex is subject to allosteric regulation and that there is communication between the nuclease and ATPase active sites, the underlying mechanisms are poorly understood. We performed statistical coupling analysis on Mre11 and Rad50 to predict linked residues based on their ...[more]