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Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella.


ABSTRACT: We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.

SUBMITTER: Depledge DP 

PROVIDER: S-EPMC5079377 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella.

Depledge Daniel P DP   Brown Julianne J   Macanovic Jasna J   Underhill Gill G   Breuer Judith J  

The Journal of infectious diseases 20160828 9


We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient. ...[more]

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