Ontology highlight
ABSTRACT:
SUBMITTER: Gabriel E
PROVIDER: S-EPMC4972140 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Gabriel Elke E Wason Arpit A Ramani Anand A Gooi Li Ming LM Keller Patrick P Pozniakovsky Andrei A Poser Ina I Noack Florian F Telugu Narasimha Swamy NS Calegari Federico F Šarić Tomo T Hescheler Jürgen J Hyman Anthony A AA Gottardo Marco M Callaini Giuliano G Alkuraya Fowzan Sami FS Gopalakrishnan Jay J
The EMBO journal 20160229 8
A mutation in the centrosomal-P4.1-associated protein (CPAP) causes Seckel syndrome with microcephaly, which is suggested to arise from a decline in neural progenitor cells (NPCs) during development. However, mechanisms ofNPCs maintenance remain unclear. Here, we report an unexpected role for the cilium inNPCs maintenance and identifyCPAPas a negative regulator of ciliary length independent of its role in centrosome biogenesis. At the onset of cilium disassembly,CPAPprovides a scaffold for the c ...[more]