Ontology highlight
ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC5079683 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Qin Yong Y Roszik Jason J Chattopadhyay Chandrani C Hashimoto Yuuri Y Liu Chengwen C Cooper Zachary A ZA Wargo Jennifer A JA Hwu Patrick P Ekmekcioglu Suhendan S Grimm Elizabeth A EA
Molecular cancer therapeutics 20160725 10
Melanoma is molecularly and structurally heterogeneous, with some tumor cells existing under hypoxic conditions. Our cell growth assays showed that under controlled hypoxic conditions, BRAF(V600E) melanoma cells rapidly became resistant to vemurafenib. By employing both a three-dimensional (3D) spheroid model and a two-dimensional (2D) hypoxic culture system to model hypoxia in vivo, we identified upregulation of HGF/MET signaling as a major mechanism associated with vemurafenib resistance as co ...[more]