Ontology highlight
ABSTRACT:
SUBMITTER: Lessard L
PROVIDER: S-EPMC5080984 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lessard Laurent L Labbé David P DP Deblois Geneviève G Bégin Louis R LR Hardy Serge S Mes-Masson Anne-Marie AM Saad Fred F Trotman Lloyd C LC Giguère Vincent V Tremblay Michel L ML
Cancer research 20120126 6
The androgen receptor (AR) signaling axis plays a key role in the pathogenesis of prostate cancer. In this study, we found that the protein tyrosine phosphatase PTP1B, a well-established regulator of metabolic signaling, was induced after androgen stimulation of AR-expressing prostate cancer cells. PTP1B induction by androgen occurred at the mRNA and protein levels to increase PTP1B activity. High-resolution chromosome mapping revealed AR recruitment to two response elements within the first int ...[more]