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Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.

ABSTRACT: The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5980762 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression.

Zhang Yajia Y   Pitchiaya Sethuramasundaram S   Cieślik Marcin M   Niknafs Yashar S YS   Tien Jean C-Y JC   Hosono Yasuyuki Y   Iyer Matthew K MK   Yazdani Sahr S   Subramaniam Shruthi S   Shukla Sudhanshu K SK   Jiang Xia X   Wang Lisha L   Liu Tzu-Ying TY   Uhl Michael M   Gawronski Alexander R AR   Qiao Yuanyuan Y   Xiao Lanbo L   Dhanasekaran Saravana M SM   Juckette Kristin M KM   Kunju Lakshmi P LP   Cao Xuhong X   Patel Utsav U   Batish Mona M   Shukla Girish C GC   Paulsen Michelle T MT   Ljungman Mats M   Jiang Hui H   Mehra Rohit R   Backofen Rolf R   Sahinalp Cenk S CS   Freier Susan M SM   Watt Andrew T AT   Guo Shuling S   Wei John T JT   Feng Felix Y FY   Malik Rohit R   Chinnaiyan Arul M AM  

Nature genetics 20180528 6

The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knoc  ...[more]

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