Ontology highlight
ABSTRACT:
SUBMITTER: Duteil D
PROVIDER: S-EPMC5081406 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Duteil Delphine D Tosic Milica M Lausecker Franziska F Nenseth Hatice Z HZ Müller Judith M JM Urban Sylvia S Willmann Dominica D Petroll Kerstin K Messaddeq Nadia N Arrigoni Laura L Manke Thomas T Kornfeld Jan-Wilhelm JW Brüning Jens C JC Zagoriy Vyacheslav V Meret Michael M Dengjel Jörn J Kanouni Toufike T Schüle Roland R
Cell reports 20161001 4
Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and upregulation of white adipose tissue (WAT)-selective gene expression. This results in the accumulation of d ...[more]