Ontology highlight
ABSTRACT:
SUBMITTER: Gorrieri G
PROVIDER: S-EPMC5081536 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gorrieri Giulia G Scudieri Paolo P Caci Emanuela E Schiavon Marco M Tomati Valeria V Sirci Francesco F Napolitano Francesco F Carrella Diego D Gianotti Ambra A Musante Ilaria I Favia Maria M Casavola Valeria V Guerra Lorenzo L Rea Federico F Ravazzolo Roberto R Di Bernardo Diego D Galietta Luis J V LJ
Scientific reports 20161027
Goblet cell hyperplasia, a feature of asthma and other respiratory diseases, is driven by the Th-2 cytokines IL-4 and IL-13. In human bronchial epithelial cells, we find that IL-4 induces the expression of many genes coding for ion channels and transporters, including TMEM16A, SLC26A4, SLC12A2, and ATP12A. At the functional level, we find that IL-4 enhances calcium- and cAMP-activated chloride/bicarbonate secretion, resulting in high bicarbonate concentration and alkaline pH in the fluid coverin ...[more]