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Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation.

ABSTRACT: Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene^TM) in Sonogashira cross-coupling and Cacchi-type annulations.

SUBMITTER: Wilson KL

PROVIDER: S-EPMC5082449 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation.

Wilson Kirsty L KL Kennedy Alan R AR Murray Jane J Greatrex Ben B Jamieson Craig C Watson Allan J B AJ

Beilstein journal of organic chemistry 20160908

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (Cyrene<sup>TM</sup>) in Sonogashira cross-coupling and Cacchi-type annulations. ...[more]

PMID: 27829904

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