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Tunable microwave-assisted method for the solvent-free and catalyst-free peracetylation of natural products.

ABSTRACT: Background: The peracetylation is a simple chemical modification that can be used to enhance the bioavailability of hydrophilic products and to obtain safe and stable pro-drugs. Results: A totally green, solvent-free and catalyst-free microwave (MW)-assisted method for peracetylation of natural products such as oleuropein, alpha-hederin, quercetin and rutin is presented. By simply tuning the MW heating program, polyols with chemical diverse -OH groups or thermolabile functionalities can be peracetylated to improve the biological activity without degradation of the natural starting molecules. An evaluation of the process greenness was performed. Conclusion: The method is potentially universally applicable for green acetylation of hydrophilic biological molecules, potentially easily scalable for industrial applications, including pharmaceutical, cosmetic and food industry.

SUBMITTER: Oliverio M

PROVIDER: S-EPMC5082547 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Tunable microwave-assisted method for the solvent-free and catalyst-free peracetylation of natural products.

Oliverio Manuela M Costanzo Paola P Nardi Monica M Calandruccio Carla C Salerno Raffaele R Procopio Antonio A

Beilstein journal of organic chemistry 20161020

<b>Background:</b> The peracetylation is a simple chemical modification that can be used to enhance the bioavailability of hydrophilic products and to obtain safe and stable pro-drugs. <b>Results:</b> A totally green, solvent-free and catalyst-free microwave (MW)-assisted method for peracetylation of natural products such as oleuropein, alpha-hederin, quercetin and rutin is presented. By simply tuning the MW heating program, polyols with chemical diverse -OH groups or thermolabile functionalitie ...[more]

PMID: 27829931

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