Ontology highlight
ABSTRACT:
SUBMITTER: Xie N
PROVIDER: S-EPMC5082782 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Xie Na N Yuan Kefei K Zhou Li L Wang Kui K Chen Hai-Ning HN Lei Yunlong Y Lan Jiang J Pu Qinqin Q Gao Wei W Zhang Lu L Shen Guobo G Li Qifu Q Xiao Hengyi H Tang Hong H Xiang Rong R He Mingliang M He Mingliang M Feng Pinghui P Nice Edouard C EC Wei Yuquan Y Zhang Haiyuan H Yang Jiayin J Huang Canhua C
Autophagy 20160615 9
Adenosine monophosphate-activated protein kinase (AMPK) is a crucial energy sensor that maintains cellular energy homeostasis. AMPK plays a critical role in macroautophagy/autophagy, and autophagy facilitates hepatitis B virus (HBV) replication. To date, the intrinsic link among AMPK, autophagy and HBV production remains to be elucidated. Here, we demonstrate that PRKAA (a catalytic subunit of AMPK) is activated in response to HBV-induced oxidative stress, which in turn decreases the production ...[more]