Ontology highlight
ABSTRACT:
SUBMITTER: Xie N
PROVIDER: S-EPMC5082782 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Autophagy 20160615 9
Adenosine monophosphate-activated protein kinase (AMPK) is a crucial energy sensor that maintains cellular energy homeostasis. AMPK plays a critical role in macroautophagy/autophagy, and autophagy facilitates hepatitis B virus (HBV) replication. To date, the intrinsic link among AMPK, autophagy and HBV production remains to be elucidated. Here, we demonstrate that PRKAA (a catalytic subunit of AMPK) is activated in response to HBV-induced oxidative stress, which in turn decreases the production ...[more]