Ontology highlight
ABSTRACT:
SUBMITTER: Ito T
PROVIDER: S-EPMC5084673 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ito Takeshi T Matsubara Daisuke D Tanaka Ichidai I Makiya Kanae K Tanei Zen-Ichi ZI Kumagai Yuki Y Shiu Shu-Jen SJ Nakaoka Hiroki J HJ Ishikawa Shumpei S Isagawa Takayuki T Morikawa Teppei T Shinozaki-Ushiku Aya A Goto Yasushi Y Nakano Tomoyuki T Tsuchiya Takehiro T Tsubochi Hiroyoshi H Komura Daisuke D Aburatani Hiroyuki H Dobashi Yoh Y Nakajima Jun J Endo Shunsuke S Fukayama Masashi M Sekido Yoshitaka Y Niki Toshiro T Murakami Yoshinori Y
Cancer science 20160909 10
YAP1, the main Hippo pathway effector, is a potent oncogene and is overexpressed in non-small-cell lung cancer (NSCLC); however, the YAP1 expression pattern in small-cell lung cancer (SCLC) has not yet been elucidated in detail. We report that the loss of YAP1 is a special feature of high-grade neuroendocrine lung tumors. A hierarchical cluster analysis of 15 high-grade neuroendocrine tumor cell lines containing 14 SCLC cell lines that depended on the genes of Hippo pathway molecules and neuroen ...[more]