Ontology highlight
ABSTRACT:
SUBMITTER: McColl K
PROVIDER: S-EPMC5650296 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
McColl Karen K Wildey Gary G Sakre Nneha N Lipka Mary Beth MB Behtaj Mohadese M Kresak Adam A Chen Yanwen Y Yang Michael M Velcheti Vamsidhar V Fu Pingfu P Dowlati Afshin A
Oncotarget 20170828 43
The majority of small cell lung cancer (SCLC) patients demonstrate initial chemo-sensitivity, whereas a distinct subgroup of SCLC patients, termed chemo-refractory, do not respond to treatment. There is little understanding of how to distinguish these patients prior to disease treatment. Here we used gene expression profiling to stratify SCLC into subgroups and characterized a molecular phenotype that may identify, in part, chemo-refractive SCLC patients. Two subgroups of SCLC were identified in ...[more]