Regulation of microglial survival and proliferation in health and diseases.
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ABSTRACT:
SUBMITTER: Ulland TK
PROVIDER: S-EPMC5084693 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
Regulation of microglial survival and proliferation in health and diseases.
Ulland Tyler K TK Wang Yaming Y Colonna Marco M
Seminars in immunology 20151201 6
Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regard ...[more]
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