Ontology highlight
ABSTRACT:
SUBMITTER: Johnson EC
PROVIDER: S-EPMC5085024 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Johnson Emma C EC Bjelland Douglas W DW Howrigan Daniel P DP Abdellaoui Abdel A Breen Gerome G Borglum Anders A Cichon Sven S Degenhardt Franziska F Forstner Andreas J AJ Frank Josef J Genovese Giulio G Heilmann-Heimbach Stefanie S Herms Stefan S Hoffman Per P Maier Wolfgang W Mattheisen Manuel M Morris Derek D Mowry Bryan B Müller-Mhysok Betram B Neale Benjamin B Nenadic Igor I Nöthen Markus M MM O'Dushlaine Colm C Rietschel Marcella M Ruderfer Douglas M DM Rujescu Dan D Schulze Thomas G TG Simonson Matthew A MA Stahl Eli E Strohmaier Jana J Witt Stephanie H SH Sullivan Patrick F PF Keller Matthew C MC
PLoS genetics 20161028 10
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868) ...[more]