Ontology highlight
ABSTRACT:
SUBMITTER: Choo Z
PROVIDER: S-EPMC5085151 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Choo Zhang'e Z Koh Rachel Yu Lin RY Wallis Karin K Koh Timothy Jia Wei TJ Kuick Chik Hong CH Sobrado Veronica V Kenchappa Rajappa S RS Loh Amos Hong Pheng AH Soh Shui Yen SY Schlisio Susanne S Chang Kenneth Tou En KT Chen Zhi Xiong ZX
Oncotarget 20160601 23
Neuroblastoma is an aggressive, relapse-prone childhood tumor of the sympathetic nervous system. Current treatment modalities do not fully exploit the genetic basis between the different molecular subtypes and little is known about the targets discovered in recent mutational and genetic studies. Neuroblastomas with poor prognosis are often characterized by 1p36 deletion, containing the kinesin gene KIF1B. Its beta isoform, KIF1Bβ, is required for NGF withdrawal-dependent apoptosis, mediated by t ...[more]