Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC6446871 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhu Caihong C Li Bei B Frontzek Karl K Liu Yingjun Y Aguzzi Adriano A
The Journal of experimental medicine 20190306 4
SARM1 (sterile α and HEAT/armadillo motif-containing protein) is a member of the MyD88 (myeloid differentiation primary response gene 88) family, which mediates innate immune responses. Because inactivation of SARM1 prevents various forms of axonal degeneration, we tested whether it might protect against prion-induced neurotoxicity. Instead, we found that SARM1 deficiency exacerbates the progression of prion pathogenesis. This deleterious effect was not due to SARM1-dependent modulation of prion ...[more]