Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.
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ABSTRACT:
SUBMITTER: Sawada T
PROVIDER: S-EPMC5085213 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations.
Sawada Takeshi T Yamamoto Eiichiro E Yamano Hiro-O HO Nojima Masanori M Harada Taku T Maruyama Reo R Ashida Masami M Aoki Hironori H Matsushita Hiro-O HO Yoshikawa Kenjiro K Harada Eiji E Tanaka Yoshihito Y Wakita Shigenori S Niinuma Takeshi T Kai Masahiro M Eizuka Makoto M Sugai Tamotsu T Suzuki Hiromu H
Oncotarget 20160601 23
To clarify the molecular and clinicopathological characteristics of colorectal serrated lesions, we assessed the DNA methylation of cancer-associated genes in a cohort of BRAF-mutant precancerous lesions from 94 individuals. We then compared those results with the lesions' clinicopathological features, especially colorectal subsites. The lesions included hyperplastic polyps (n = 16), traditional serrated adenomas (TSAs) (n = 15), TSAs with sessile serrated adenomas (SSAs) (n = 6), SSAs (n = 49) ...[more]
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