Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC5085236 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Liu Wen W Beck Julia J Schmidt Laura C LC Roolf Catrin C Pews-Davtyan Anahit A Rütgen Barbara C BC Hammer Sabine S Willenbrock Saskia S Sekora Anett A Rolfs Arndt A Beller Matthias M Brenig Bertram B Nolte Ingo I Junghanss Christian C Schütz Ekkehard E Murua Escobar Hugo H
Oncotarget 20160601 23
Protein kinase inhibitors are widely used in chemotherapeutic cancer regimens. Maleimide derivatives such as SB-216763 act as GSK-3 inhibitor targeting cell proliferation, cell death and cell cycle progression.Herein, the two arylindolylmaleimide derivatives PDA-66 and PDA-377 were evaluated as potential chemotherapeutic agents on canine B-cell lymphoma cell lines. Canine lymphoma represents a naturally occurring model closely resembling the human high-grade non-Hodgkin's lymphoma (NHL). PDA-66 ...[more]