Structure of the NS3 helicase from Zika virus.
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ABSTRACT:
SUBMITTER: Jain R
PROVIDER: S-EPMC5085289 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Structure of the NS3 helicase from Zika virus.
Jain Rinku R Coloma Javier J García-Sastre Adolfo A Aggarwal Aneel K AK
Nature structural & molecular biology 20160711 8
Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery. ...[more]
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