Ontology highlight
ABSTRACT:
SUBMITTER: Kedzierska H
PROVIDER: S-EPMC5085631 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kędzierska Hanna H Popławski Piotr P Hoser Grażyna G Rybicka Beata B Rodzik Katarzyna K Sokół Elżbieta E Bogusławska Joanna J Tański Zbigniew Z Fogtman Anna A Koblowska Marta M Piekiełko-Witkowska Agnieszka A
International journal of molecular sciences 20160928 10
Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing. Previous studies suggested that SRSF2 can contribute to carcinogenic processes. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, highly aggressive and difficult to treat, mainly due to resistance to apoptosis. In this study we hypothesized that SRSF2 contributes to the regulation of apoptosis in ccRCC. Using tissue s ...[more]