Ontology highlight
ABSTRACT:
SUBMITTER: Palumbo R
PROVIDER: S-EPMC5085647 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Palumbo Rosanna R Gogliettino Marta M Cocca Ennio E Iannitti Roberta R Sandomenico Annamaria A Ruvo Menotti M Balestrieri Marco M Rossi Mosè M Palmieri Gianna G
International journal of molecular sciences 20160923 10
The proteasome is a multienzymatic complex that controls the half-life of the majority of intracellular proteins, including those involved in apoptosis and cell-cycle progression. Recently, proteasome inhibition has been shown to be an effective anticancer strategy, although its downregulation is often accompanied by severe undesired side effects. We previously reported that the inhibition of acylpeptide hydrolase (APEH) by the peptide SsCEI 4 can significantly affect the proteasome activity in ...[more]