Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC7074174 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liu Hong H Zang Lili L Zhao Jun J Wang Zhaolin Z Li Lingyun L
Oncology letters 20200303 4
Paeoniflorin (PF) has been demonstrated to exert tumor suppressive functions in various types of human cancer. However, the mechanisms of PF-mediated anti-tumor activity have not been fully elucidated. S-phase kinase associated protein 2 (Skp2) has been characterized as an oncoprotein that contributes to carcinogenesis. Therefore, the inhibition of Skp2 may be a useful approach for the treatment of various types of human cancer. The present study explored whether PF inhibited the expression of S ...[more]