Ontology highlight
ABSTRACT:
SUBMITTER: Nys M
PROVIDER: S-EPMC5087063 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nys Mieke M Wijckmans Eveline E Farinha Ana A Yoluk Özge Ö Andersson Magnus M Brams Marijke M Spurny Radovan R Peigneur Steve S Tytgat Jan J Lindahl Erik E Ulens Chris C
Proceedings of the National Academy of Sciences of the United States of America 20161010 43
Pentameric ligand-gated ion channels or Cys-loop receptors are responsible for fast inhibitory or excitatory synaptic transmission. The antipsychotic compound chlorpromazine is a widely used tool to probe the ion channel pore of the nicotinic acetylcholine receptor, which is a prototypical Cys-loop receptor. In this study, we determine the molecular determinants of chlorpromazine binding in the Erwinia ligand-gated ion channel (ELIC). We report the X-ray crystal structures of ELIC in complex wit ...[more]