Ontology highlight
ABSTRACT:
SUBMITTER: Talibov VO
PROVIDER: S-EPMC8248052 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Talibov Vladimir O VO Fabini Edoardo E FitzGerald Edward A EA Tedesco Daniele D Cederfeldt Daniela D Talu Martin J MJ Rachman Moira M MM Mihalic Filip F Manoni Elisabetta E Naldi Marina M Sanese Paola P Forte Giovanna G Lepore Signorile Martina M Barril Xavier X Simone Cristiano C Bartolini Manuela M Dobritzsch Doreen D Del Rio Alberto A Danielson U Helena UH
Chembiochem : a European journal of chemical biology 20210211 9
SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a set of drug-like compounds was screened in a biosensor-based competition assay. Diperodon was identified as an allosteric ligand; its R and S enantiomers were isolated, and their affinities to SMYD3 w ...[more]