Ontology highlight
ABSTRACT:
SUBMITTER: Sherry-Lynes MM
PROVIDER: S-EPMC5383422 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Sherry-Lynes Maureen M MM Sengupta Sejuti S Kulkarni Shreya S Cochran Brent H BH
PloS one 20170406 4
The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma. Here we show that STAT3 inhibition leads to the upregulation of the histone H3K27me2/3 demethylase Jmjd3 (KDM6B), which can reverse polycomb complex-mediated repression of tissue specific genes. STAT3 binds to the Jmjd3 promoter, suggesting that Jmjd3 is a direct target of STAT3. Overexpression of Jmjd3 slows glioblastoma st ...[more]