Ontology highlight
ABSTRACT:
SUBMITTER: Gammons MV
PROVIDER: S-EPMC5087658 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gammons Melissa V MV Rutherford Trevor J TJ Steinhart Zachary Z Angers Stephane S Bienz Mariann M
Journal of cell science 20161001 20
Dishevelled (DVL) assembles Wnt signalosomes through dynamic head-to-tail polymerisation by means of its DIX domain. It thus transduces Wnt signals to cytoplasmic effectors including β-catenin, to control cell fates during normal development, tissue homeostasis and also in cancer. To date, most functional studies of Dishevelled relied on its Wnt-independent signalling activity resulting from overexpression, which is sufficient to trigger polymerisation, bypassing the requirement for Wnt signals. ...[more]