Ontology highlight
ABSTRACT:
SUBMITTER: Wong HC
PROVIDER: S-EPMC4381838 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Wong H C HC Mao J J Nguyen J T JT Srinivas S S Zhang W W Liu B B Li L L Wu D D Zheng J J
Nature structural biology 20001201 12
The DEP domain of Dishevelled (Dvl) proteins transduces signals to effector proteins downstream of Dvl in the Wnt pathway. Here we report that DEP-containing mutants inhibit Wnt-induced, but not Dvl-induced, activation of the transcription factor Lef-1. This inhibitory effect is weakened by a K434M mutation. Nuclear magnetic resonance spectroscopy revealed that the DEP domain of mouse Dvl1 comprises a three-helix bundle, a beta-hairpin 'arm' and two short beta-strands at the C-terminal region. L ...[more]