Ontology highlight
ABSTRACT:
SUBMITTER: Uhl B
PROVIDER: S-EPMC5087948 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Uhl Barbara B Dietrich Dimo D Branchi Vittorio V Semaan Alexander A Schaefer Pauline P Gevensleben Heidrun H Rostamzadeh Babak B Lingohr Philipp P Schäfer Nico N Kalff Jörg C JC Kristiansen Glen G Matthaei Hanno H
PloS one 20161031 10
Biliary tract cancers (BTC) are rare but highly aggressive malignant epithelial tumors. In order to improve the outcome in this lethal disease, novel biomarkers for diagnosis, prognosis, and therapy response prediction are urgently needed. DNA promoter methylation of PITX2 variants (PITX2ab, PITX2c) and intragenic methylation of the PITX2 adjacent non-coding RNA (PANCR) were investigated by methylations-specific qPCR assays in formalin-fixed paraffin-embedded tissue from 80 patients after resect ...[more]