Ontology highlight
ABSTRACT:
SUBMITTER: von Schimmelmann M
PROVIDER: S-EPMC5088783 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
von Schimmelmann Melanie M Feinberg Philip A PA Sullivan Josefa M JM Ku Stacy M SM Badimon Ana A Duff Mary Kaye MK Wang Zichen Z Lachmann Alexander A Dewell Scott S Ma'ayan Avi A Han Ming-Hu MH Tarakhovsky Alexander A Schaefer Anne A
Nature neuroscience 20160815 10
Normal brain function depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. Neuronal specification is driven by transcriptional programs that are established during early neuronal development and remain in place in the adult brain. The fidelity of neuronal specification depends on the robustness of the transcriptional program that supports the neuron type-specific gene expression patterns. Here we show that polycom ...[more]