Ontology highlight
ABSTRACT:
SUBMITTER: Beltran M
PROVIDER: S-EPMC6778522 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Beltran Manuel M Tavares Manuel M Justin Neil N Khandelwal Garima G Ambrose John J Foster Benjamin M BM Worlock Kaylee B KB Tvardovskiy Andrey A Kunzelmann Simone S Herrero Javier J Bartke Till T Gamblin Steven J SJ Wilson Jon R JR Jenner Richard G RG
Nature structural & molecular biology 20190923 10
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such knowledge would be useful for the targeted reversal of deleterious PRC2 recruitment events. Here, we show that G-tract RNA specifically removes PRC2 from genes in human and mouse cells. PRC2 preferentially binds G tracts within nascent precursor mRNA (pre-mRNA), especially within predicted G- ...[more]