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Copper(I)-Phosphinite Complexes in Click Cycloadditions: Three-Component Reactions and Preparation of 5-Iodotriazoles.

ABSTRACT: The remarkable activity displayed by copper(I)-phosphinite complexes of general formula [CuBr(L)] in two challenging cycloadditions is reported: a)?the one-pot azidonation/cycloaddition of boronic acids, NaN₃, and terminal alkynes; b)?the cycloaddition of azides and iodoalkynes. These air-stable catalysts led to very good results in both cases and the expected triazoles could be isolated in pure form under 'Click-suitable' conditions.

SUBMITTER: Perez JM

PROVIDER: S-EPMC5089671 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Copper(I)-Phosphinite Complexes in Click Cycloadditions: Three-Component Reactions and Preparation of 5-Iodotriazoles.

Pérez Juana M JM Crosbie Peter P Lal Steven S Díez-González Silvia S

ChemCatChem 20160613 13

The remarkable activity displayed by copper(I)-phosphinite complexes of general formula [CuBr(L)] in two challenging cycloadditions is reported: a) the one-pot azidonation/cycloaddition of boronic acids, NaN<sub>3</sub>, and terminal alkynes; b) the cycloaddition of azides and iodoalkynes. These air-stable catalysts led to very good results in both cases and the expected triazoles could be isolated in pure form under 'Click-suitable' conditions. ...[more]

PMID: 27840662

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