A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes.
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ABSTRACT:
SUBMITTER: Allhorn M
PROVIDER: S-EPMC5090349 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes.
Allhorn Maria M Arve Sabine S Brüggemann Holger H Lood Rolf R
Scientific reports 20161102
The role of the skin microbiota in human health is poorly understood. Here, we identified and characterized a novel antioxidant enzyme produced by the skin microbiota, designated RoxP for radical oxygenase of Propionibacterium acnes. RoxP is uniquely produced by the predominant skin bacterium P. acnes, with no homologs in other bacteria; it is highly expressed and strongly secreted into culture supernatants. We show that RoxP binds heme, reduces free radicals, and can protect molecules from oxid ...[more]
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