Dataset Information
Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.
Ontology highlight
ABSTRACT: Aims
To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls.Methods
Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward.Results
We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cues in the dorsal and ventral striatum compared with healthy controls.Conclusion
These findings provide the first evidence that alcohol-dependent participants and healthy controls differ in their effort-based valuation and motivation processing. Alcohol-dependent participants displayed a hyperactive mesolimbic reward circuitry recruited by non-drug rewards, potentially reflecting a sensitization to reward in this patient population.
SUBMITTER: Grodin EN
PROVIDER: S-EPMC5091291 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.
Alcohol and alcoholism (Oxford, Oxfordshire) 20160217 6
<h4>Aims</h4>To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls.<h4>Methods</h4>Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward.<h ...[more]