Ontology highlight
ABSTRACT:
SUBMITTER: Goo L
PROVIDER: S-EPMC5091377 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20160921 10
Chikungunya virus (CHIKV) is an alphavirus that has emerged as a global health burden. There are 3 CHIKV genotypes: Asian, West African, and Eastern/Central/South African. No licensed CHIKV vaccine is available, and whether the antibody response elicited by one genotype can neutralize heterologous genotypes is unclear. We assessed neutralizing antibody (NAb) responses of volunteers in a phase 1 study of a CHIKV vaccine against 9 viral strains representing all 3 genotypes. Minimal differences in ...[more]