Unknown

Dataset Information

0

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus.

ABSTRACT: Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, stability, and delivery characteristics.

SUBMITTER: DeZure AD 

PROVIDER: S-EPMC5137244 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Whole-Inactivated and Virus-Like Particle Vaccine Strategies for Chikungunya Virus.

DeZure Adam D AD   Berkowitz Nina M NM   Graham Barney S BS   Ledgerwood Julie E JE  

The Journal of infectious diseases 20161201 suppl 5

Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in  ...[more]

Similar Datasets

Unknown Effective chikungunya virus-like particle vaccine produced in insect cells.
| S-EPMC3597470 | biostudies-literature
Unknown A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection.
| S-EPMC2834826 | biostudies-literature
Unknown Vaccination with a chikungunya virus-like particle vaccine exacerbates disease in aged mice.
| S-EPMC6485612 | biostudies-literature
Unknown Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles.
| S-EPMC3578180 | biostudies-literature
Unknown Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration.
| S-EPMC4112805 | biostudies-other
Unknown Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
| S-EPMC3871535 | biostudies-literature
Unknown A Virus-Like Particle Vaccine Elicits Broad Neutralizing Antibody Responses in Humans to All Chikungunya Virus Genotypes.
| S-EPMC5091377 | biostudies-literature
Transcriptomics Transcription profiling by array of mouse dendritic cells stimulated with live influenza virus, influenza whole inactivated virus vaccine or subunit vaccine.
2015-02-13 | E-MTAB-3115 | biostudies-arrayexpress
Unknown Supplementation of inactivated influenza vaccine with norovirus P particle-M2e chimeric vaccine enhances protection against heterologous virus challenge in chickens.
| S-EPMC5289506 | biostudies-literature
Unknown Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions.
| S-EPMC3869236 | biostudies-literature