Ontology highlight
ABSTRACT:
SUBMITTER: Levytskyy RM
PROVIDER: S-EPMC5093085 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Levytskyy Roman M RM Germany Edward M EM Khalimonchuk Oleh O
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20160502 4
The functional integrity of mitochondria is a critical determinant of neuronal health and compromised mitochondrial function is a commonly recognized factor that underlies a plethora of neurological and neurodegenerative diseases. Metabolic demands of neural cells require high bioenergetic outputs that are often associated with enhanced production of reactive oxygen species. Unopposed accumulation of these respiratory byproducts over time leads to oxidative damage and imbalanced protein homeosta ...[more]