Dataset Information

The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD.

ABSTRACT:

Introduction

Fatigue is one of the most disabling symptoms in COPD, but little is known about the impact of fatigue on functional disability. We explored the impact of fatigue and fatigue intensity on exercise tolerance after adjusting for other factors using multivariate analysis and compared it to that of dyspnoea.

Methods

A total of 119 patients with mainly moderate-severe stable COPD (38 % women, mean age 66 years) were enrolled. We used the Medical Research Council dyspnoea scores (MRC), Manchester COPD fatigue scale (MCFS) and its three dimensions, Borg scales for fatigue and dyspnoea, six-minute walk distance (6MWD), St George's Respiratory Questionnaire, the BODE index, and the Centre for Epidemiological Study on Depression scale (CES-D), and we measured spirometry, blood gases, systemic inflammatory markers and fat-free mass index (FFMI).

Results

Fatigue measured using the MCFS was associated with 6MWD and explained 22 % of the variability in 6MWD (p < 0.001). Fatigue remained associated with 6MWD after adjusting for MRC dyspnoea, FFMI and FEV₁, FVC, PaO₂, PaCO₂, CES-D, TNF-alpha, smoking status, age and gender. We found that 33, 50 and 23 % of patients reported an increase by 2 scores on Borg scales for fatigue, dyspnoea or both at the end of the 6MWT. Fatigue scores (both before and after the 6MWT) were negatively correlated with 6MWD after adjusting for FEV₁, FFMI, CES-D score and age (p = 0.007 and 0.001, respectively).

Conclusion

In moderate stable COPD, fatigue may be a central driver of functional disability, to the same extent as dyspnoea.

SUBMITTER: Al-Shair K

PROVIDER: S-EPMC5093188 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD.

Al-Shair Khaled K Kolsum Umme U Singh Dave D Vestbo Jørgen J

Lung 20160822 6

<h4>Introduction</h4>Fatigue is one of the most disabling symptoms in COPD, but little is known about the impact of fatigue on functional disability. We explored the impact of fatigue and fatigue intensity on exercise tolerance after adjusting for other factors using multivariate analysis and compared it to that of dyspnoea.<h4>Methods</h4>A total of 119 patients with mainly moderate-severe stable COPD (38 % women, mean age 66 years) were enrolled. We used the Medical Research Council dyspnoea s ...[more]

PMID: 27549363

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Dataset Information

The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD.

Introduction

Methods

Results

Conclusion

Publications

The Effect of Fatigue and Fatigue Intensity on Exercise Tolerance in Moderate COPD.

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