Ontology highlight
ABSTRACT:
SUBMITTER: Brown JW
PROVIDER: S-EPMC5093550 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Brown James W P JW Buell Alexander K AK Michaels Thomas C T TC Meisl Georg G Carozza Jacqueline J Flagmeier Patrick P Vendruscolo Michele M Knowles Tuomas P J TP Dobson Christopher M CM Galvagnion Céline C
Scientific reports 20161103
α-Synuclein is an intrinsically disordered protein that is associated with the pathogenesis of Parkinson's disease through the processes involved in the formation of amyloid fibrils. α and β-synuclein are homologous proteins found at comparable levels in presynaptic terminals but β-synuclein has a greatly reduced propensity to aggregate and indeed has been found to inhibit α-synuclein aggregation. In this paper, we describe how sequence differences between α- and β-synuclein affect individual mi ...[more]