Ontology highlight
ABSTRACT:
SUBMITTER: Bonny M
PROVIDER: S-EPMC5093555 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bonny Mike M Hui Xin X Schweizer Julia J Kaestner Lars L Zeug André A Kruse Karsten K Lipp Peter P
Scientific reports 20161103
Conventional protein kinase Cs (cPKCs) are key signaling proteins for transducing intracellular Ca<sup>2+</sup> signals into downstream phosphorylation events. However, the lifetime of individual membrane-bound activated cPKCs is an order of magnitude shorter than the average time needed for target-protein phosphorylation. Here, we employed intermolecular Förster resonance energy transfer (FRET) in living cells combined with computational analysis to study the spatial organization of cPKCs bound ...[more]