Trinuclear Calcium Site in the C2 Domain of PKCα/γ Is Prone to Lithium Attack.

ABSTRACT: Lithium (Li⁺) is the first-line therapy for bipolar disorder and a candidate drug for various diseases such as amyotrophic lateral sclerosis, multiple sclerosis, and stroke. Despite being the captivating subject of many studies, the mechanism of lithium's therapeutic action remains unclear. To date, it has been shown that Li⁺ competes with Mg²⁺ and Na⁺ to normalize the activity of inositol and neurotransmitter-related signaling proteins, respectively. Furthermore, Li⁺ may co-bind with Mg²⁺-loaded adenosine or guanosine triphosphate to alter the complex's susceptibility to hydrolysis and mediate cellular signaling. Bipolar disorder patients exhibit abnormally high cytosolic Ca²⁺ levels and protein kinase C (PKC) hy

SUBMITTER: Grauffel C 

PROVIDER: S-EPMC8359144 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature