Ontology highlight
ABSTRACT:
SUBMITTER: Shahi P
PROVIDER: S-EPMC5093748 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Shahi Preeti P Trebicz-Geffen Meirav M Nagaraja Shruti S Hertz Rivka R Baumel-Alterzon Sharon S Methling Karen K Lalk Michael M Mazumder Mohit M Samudrala Gourinath G Ankri Serge S
Scientific reports 20161103
Adaptation of the Entamoeba histolytica parasite to toxic levels of nitric oxide (NO) that are produced by phagocytes may be essential for the establishment of chronic amebiasis and the parasite's survival in its host. In order to obtain insight into the mechanism of E. histolytica's adaptation to NO, E. histolytica trophozoites were progressively adapted to increasing concentrations of the NO donor drug, S-nitrosoglutathione (GSNO) up to a concentration of 110 μM. The transcriptome of NO adapte ...[more]